Endocrine Abstracts

Introduction: Recent studies have highlighted zinc’s dynamic role as a cellular second messenger in the control of insulin signaling and glucose homeostasis. The aim of our study was to assess the concentration of serum and urinary zinc levels in type 2 diabetic patients and to investigate the correlation between this variable and glycemic control.Methods: Total 54 type 2 diabetic patients and 23 non diabetic healthy subjects (age matched) were enro...

Background: Severe hypercalcemia, defined as a serum calcium concentration ≥ 3.5 mmol/l or > 3 mmol/l associated with symptoms and signs of acute calcium intoxication, is a rare but a potentially life threatening condition. The aim of this study was to assess clinical, paraclinical, etiological and therapeutic features of severe hypercalcemia and to determine its outcome.Methods: It was a retrospective, descriptive and comparative study conduct...

Background: The primary empty sella (PES) is radiologically defined as partial when less than 50% of the sella is filled with cerebrospinal fluid (CSF) and pituitary gland thickness is ≥3 mm or total when more than 50% of the sella is filled with CSF and the gland thickness is ≤2 mm in diameter.The aim of our study was to evaluate clinical and radiological aspects of PES.Methods: We retrospectively evaluated clinical features and radiological...

Background: The term primary empty sella (PES) makes reference to the herniation of the subarachnoid space within the sella turcica in patients with no history of pituitary tumor,surgery or radiotherapy. The aim of our study was to evaluate hormonal abnormalities associated with PES.Methods: Thirty-six patients with PES were retrospectively analysed over a 24-year period [1992-2016].Patients were evaluated for pituitary function with basal hormone levels...

IntroductionVon Hippel-Lindau (VHL) syndrome is an autosomal dominant disease resulting in a susceptibility to develop central nervous system and retinal hemangioblastomas, endolymphatic sac tumors, renal clear cell carcinoma and pheochromocytoma. Pheochromocytoma occurs usually at a younger age and tends to be bilateral in VHL syndrome. Herein, we describe a case of VHL syndrome with cerebellar hemangioblastoma, bilateral pheochromocytoma and kidney tum...

IntroductionThe adrenocortical carcinoma(ACC) is a rare malignant tumor arising from the adrenal cortex, it is usually associated to abnormal hormone secretion, but sometimes it is nonfunctioning, leading to a delayed diagnosis with a locally advanced and/or a metastatic disease. ObservationWe report the case of a 42 year-old woman with no medical history who consulted for chronic epigastralgia. On physical e...

IntroductionInsulinoma is a rare neuroendocrine tumor with an incidence of 1 to 4 per million person-years. It is the most frequent endocrine tumor of the pancreas and is revealed by a spontaneous hypoglycemia in the absence of insulin or any antidiabetic medication.Only few cases of confirmed insulinoma with pregnancy have been described in the literature. We describe a case of insulinoma discovered early in pregnancy.Case report<...

IntroductionInsulinoma is the most frequent endocrine tumor of the pancreas and a diagnosis challenge in all cases of spontaneous hypoglycemia. The confirmation of hypoglycemia is the first step of the diagnosis before initiating the complementary investigations to confirm the insulinoma and determine its localization. The aim of this study was to investigate the diagnosis of insulinoma in a setting of organic hypoglycemia.Methods<...

IntroductionPituitary stalk interruption syndrome is an entity radiologically defined by the association of an absent or thin pituitary stalk, an ectopic posterior lobe and a hypoplasia or aplasia anterior lobe. It can manifest as a several of hormonal deficiencies. The circumstances of discovery are multiple. This case illustrates a pituitary stalk interruption syndrome revealed by a growth retardation.Case presentation<p clas...

IntroductionLymphocytic hypophysitis is an autoimmune inflammatory pathology of the pituitary gland responsible for partial or global hypopituitarism. In this context, we report a clinical case illustrating this entity.Clinical caseA 31-year-old woman with a family history of hypothyroidism and a personal history of vitiligo was seen in the 8th month of pregnancy for headaches that have progressed rapidly in ...